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This document specifies the applicable requirements related to the design and the operation of confinement and ventilation systems for fusion facilities for tritium fuels and tritium fuel handling facilities specific for fusion applications for peaceful purposes using high tritium inventories, as well as for their specialized buildings such as hot cells, examination laboratories, emergency management centres, radioactive waste treatment and storage facilities. In most countries, a tritium quantity is declared as high for tritium inventories higher than a range of 10 g to 100 g. In the tritium fusion facilities in the scope of this document, the tritium inventory is deemed to be higher than this range for the whole site. This document applies especially to confinement and ventilation systems that ensure the safety function of nuclear facilities involved in nuclear fusion with the goal to protect the workers, the public and the environment from the dissemination of radioactive contamination originating from the operation of these installations, and in particular from airborne tritium contamination with adequate confinement systems.